Precision Medicine in Type 2 Diabetes
and Cardiovascular disease

Berzelius symposium 91

31 August–1 September 2016 at Hotel Skansen in Båstad, Sweden

Purpose statement: CVD and type 2 diabetes are devastating and costly diseases whose prevalence is increasing rapidly around the world, projected to exceed billions of people worldwide within the next decades. Although drug and lifestyle interventions are used widely to prevent and treat CVD and diabetes, neither is highly effective; for example, in high risk adults, intensive lifestyle intervention delays the onset of disease by roughly 3-years and with metformin by 18-months compared to placebo control intervention (Knowler et al, Lancet, 2009), with diabetes “prevention” being the exception, rather than the rule.

Moreover, whilst some patients respond very well to therapies, others benefit little or not at all, progressing rapidly through the pre-diabetic phase of beta-cell decline and later developing life-threatening complications such as retinopathy, nephropathy, peripheral neuropathy, and cardiovascular disease. As such, there is an urgent need to develop innovative and effective prevention and treatment strategies. Human biology is complex and people differ in their genetic and molecular characteristics, which underlies the variable response to interventions and rates of disease progression. Thus, a huge, as yet unrealised opportunity exists to optimize the prevention and treatment of CVD and type 2 diabetes by tailoring therapies to the patient’s unique biology. This concept is often termed “precision medicine”. This conference will bring together thought-leaders in diabetes precision medicine who will present the state-of-the-science and discuss future prospects.

Description >>

Significance >>

Dissemination >>

Participants: The conference is open to all active scientists working in the field, but we will seek to ensure an even gender and career stage distribution amongst attendees by advertising more intensively to underrepresented delegate groups.

The symposium is endorsed by the Swedish Society of Medicine and supported by the Swedish Research Council (Vetenskapsrådet), Hjärt Lungfonden, EpiHealth, Eli Lilly, Sanofi Aventis, Novo Nordisk, Exodiab

Organizer: Paul Franks, paul.franks@med.lu.se

General Information >>


Tuesday, August 30th
Registration for delegates start at 4 pm.

Wednesday, August 31st
09.00-09.15 Welcome and introduction.
Paul Franks,
Lund University Diabetes Center, Sweden
09.15-10.00 Precision medicine: where are we and where are we going?
Leif Groop, Lund University Diabetes Center, Sweden

Chair: Tim Frayling, Exeter, UK

10.00-10.45 What industry wants from academic partnerships in precision medicine.
Hartmut Ruetten
, Sanofi, Germany
10.45-11.15 Coffee break  (poster session 1)
11.15-12.15 Why national initiatives and global collaborations are needed and how they are taking shape. Phil Smith, NIDDK, US
12.15-13.30 Lunch
13.30-14.15 The genetics of therapeutic response. Jose Florez, Harvard, US

Chair: Maria Gomez, Malmö, Sweden
14.15-15.00 Is genotype-guided lifestyle therapy on the horizon?
Anna Krook
, Karolinska Institutet, Sweden
15.00-15.30 Coffee break  (poster session 2)
15.30-16.15 A translational approach to resolve T2D pathogenesis.
Hindrik Mulder, Lund University

Chair: Guy Rutter, London, UK

16.15-17.00 From genomics to precision medicine: Uncovering and manipulating the circuitry of non-coding variants. Manolis Kellis, MIT, US

17.00-17.45 Using human genetics and genomics to unravel causal mechanisms for diabetes. Anna Gloyn, Oxford, UK

19.00-22.00 Symposium dinner
Thursday, September 1st
09.00-09.45 Genetics of obesity: Can an old dog teach us new tricks? Giles Yeo, Cambridge, UK

Chair: Tove Fall, Uppsala Sweden
09.45-10.30 New insights from combining genetics with clinical diabetes. Andrew Hattersley, Exeter, UK
10.30-11.15 Precision Medicine: iPOP and hPOP profiling to manage health and disease and
understand human variation. Mike Snyder, Stanford, US
11.15-12.00 From p-values to proteins; from proteins to personalisation (maybe).
Mark McCarthy, Oxford, UK

12.00-13.00 Lunch
13.00-14.00 Debate: precision medicine will transform patient care for the better:
for: Ewan Pearson, University of Dundee, UK
against: Simon Griffin, University of Cambridge, UK

Chair: Nick Timpson, Bristol, UK
14.00-14.45 Current trends and standards in the genomics of clinical traits and complex diseases. Myles Axton, Cheif Editor, Nature Genetics
Chair: Marju Orho Melander, Malmö, Sweden 
14.45-15.00 Closing remarks. Paul Franks

More information: annie.melin@sls.se